1) Are the CPUs overtaxed?
2) Are one or more processes using most of the CPU power?
3) Is swap space usage increasing?
5) Is the system spending time waiting for I/O?
6) Is the system writing or reading from disk too often?
7) Is the system saturating the network card?
8) Is a process using too much RAM? (Is its Resident Set Size increasing over time?)
9) What type of memory is a process using? (cat /proc/
10) Is the process stack size increasing? (VmStk)
11) Is shared memory use increasing?